Inhibitory Effects of Lactulose on Enteric Bacterial Dynamics and Gut Permeability in Bile-Duct Ligated Rats

Background and Aim: The prebiotic potential of lactulose is well known, but its effect to inhibit enteric bacterial dynamics gut permeability has not yet been investigated in experimental studies. present study aims assess the effects on a model bile duct ligation Wistar rats. Methods: rats were assigned into 3 groups, Sham-operated control, ligated (BDL) BDL+ Lac group 28th day ligation. Animals BDL + groups treated with (1.0 g/kg), administrated by gavage, once for 7 days. Bacterial translocation organs overgrowth as indicators levels DAO D-lactate biochemical makers measured each group. Results: colony forming units (CFU) spleen liver BDL+Lac was significantly decreased compared (P<0.01) significant decrease CFU seen intestinal lavage (P<0.01). On other hand, Lactulose revealed inhibitory evidence decreasing plasma activity this model. Conclusion: These results indicate that can overgrowth, (BT) increasing opening mucosa tight junction ductal obstruction obviate even systemic inflammatory response syndrome (SIRS) multiple organ dysfunction (MODS) induced obstructive jaundice.